Toyota Sequoia
Like all the other Toyotas on this list, this one is also a very reliable one, but in a large package. Its 5.7L V8 engine is paired with a 6-speed transmission which helps it handle and bear the most extreme conditions, driving or neglect. This means that a well-maintained Toyota Sequoia can easily reach the 250,000-mile marker without any issues. It may not be so good in terms of fuel consumption, but it is still considered a very good full-size SUV.
Chevrolet Silverado 3500HD
Speaking of heavy-duty vehicles, the Chevrolet Silverado 3500HD is one of the most trusted and popular in this category. It can be invisible when it has a Duramax® 6.6L Turbo-Diesel V8, enduring all kinds of abuse on the road and still easily reach 250,000 of mileage. When in a standard frame, it is equipped with Vortec® 6.0L petrol V8, which makes covering thousands of miles an easy thing to do.